Skeletal Muscle Ultrastructural Pathology In Multihormonal Disorder

Abstract

Several endocrine disorders with increase or deficiency of hormone production may present a skeletal muscle compromise. Those conditions have been considered as metabolic myopathies. Nevertheless, some pathological abnormalities, mainly microvascular changes and the existence of a cell infiltrate, found in endocrine disorders with an autoimmune origin (primary hipothyroidism, hyperthyroidism associated with Graves disease, diabetes mellitus) have permitted classifing them as inflammatory myopathies. Although muscle pathology in diseases with isolated hormone production alteration has been extensively studied, this investigation has not been realized in patients with abnormalities in several endocrine glands. In this work we report the skeletal muscle ultrastructural pathology in a patient with multihormonal disorder.A 19 years old male patient presented dwarfism with lack of muscular and sexual development. Plasma levels of thyroxin, Cortisol, growth hormone, testosterone, LH and FSH were low . TSH plasma levels were high.