Abstract
SUMMARY:This review evaluates the theoretical background and experimental data behind a new development: the replacement therapy of deficient central cholinergic systems with the dietary precursors choline or lecithin. Cholinergic deficiency states are possibly present in five neurological entities: Huntington's chorea, Tardive Dyskinesia, Gilles de la Tourette's disease, Friedreich's ataxia and presenile dementia. Preliminary data from various laboratories, including our own, in each of these disorders indicate that some clinical improvement can occasionally be seen, and that this approach deserves further investigation.
Publisher
Cambridge University Press (CUP)
Subject
Neurology (clinical),Neurology,General Medicine
Reference76 articles.
1. HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN
2. Physostigmine: antidote for anticholinergic poisoning;Snyder;Minn. Med,1975
3. Cholinergic and dopaminergic mechanisms in Huntington's chorea
4. Huntington's Chorea
5. Comparative studies of substrates and inhibitors of choline transport and choline acetyltransferase;Barker;J. Pharmacol. Exptl. Ther,1975
Cited by
58 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献