Comparison of Clinical Efficacy of 0.1% Intralesional Bleomycin Solution and 0.05% Intralesional bleomycin Solution in Patients with Warts

Abstract

Background: Warts are the hard, hyperkeratotic benign growths over the skin caused by human papilloma virus. It is one of the common skin conditions presented to the outpatient department. Various treatment options are available with variable success but sometimes it is resistant to treatment due to its depth in the dermis and relapsing nature. Aim: To compare clinical efficacy of 0.1% intralesional bleomycin solution and 0.05% intralesionalbleomycin solution in the patients with warts. Study settings & design: Experimental, Dermatology, LUMHS Jamshoro Duration: 1st January 2018 to 30th June 2018 Methods: 90 patients with persistent common warts were enrolled. Patients were examined and number of warts located on right and left hand, feet and leg of each patient were categorized in two groups as right sided group and left sided group respectively. The two concentrations of bleomycin were randomly adminitered to either right sided and left sided warts which are called, the lesion A in which 0.1% IL bleomycin solution was injected and the lesion B in which 0.05% IL bleomycin solution was injected respectively. The Response of the both therapies was assessed by measuring the size of warty lesions on 6thweek. Then patient was advised to report at the end of 14th week to observe any recurrence in the treated lesions and to assess the final clinical efficacy. Results: - Mean age of patients was 25.36 ± 6.09 years. There were 50(55.56%) male and 40(44.44%) females. Clinical efficacy as per operational definition i.e. Complete disappeared or >50% regression in size of warts with no recurrence was significantly high in lesion A than lesion B [93.3% vs. 68.9%; p=0.0005]. Regarding number of warts in patients, 86.1% of the warts were cured in lesion A while 64.9% were cure in lesion B. The difference was statistically significant. Conclusion: - Our results support that 0.1% IL Bleomycin is more effective in the treatment of viral warts as compared to 0.05% bleomycin. Keywords: Common Warts, Intralesional, Bleomycin treatment