Interactive effect of oral anti-hyperglycaemic or anti–hypertensive drugs on the inhibitory and bactericidal activity of first line anti-TB drugs against M. tuberculosis

Author:

Trivedi Priyanka,Chaturvedi VinitaORCID

Abstract

Co-existence of life style disorders, like, Diabetes or Hypertension, increases risk of, treatment failure, deaths and developing drug-resistant TB. Concomitant administration of drugs to treat dual/multi-morbidities may alter their effectiveness, in additive/synergistic or adverse/antagonistic manner. We evaluated interactive effect of 7 anti-hyperglycaemic (HG) and 6 anti-hypertensive (HT) drugs on the inhibitory (MICs) and bactericidal (% killing of intracellular bacilli) activities of anti-TB drugs, Isoniazid (INH), Rifampicin (RFM), Ethambutol (EMB) and Streptomycin (STR) againstM.tuberculosis. Five anti-HG drugs, namely, Acarbose, Acetohexamide, Glyburide, Repaglinide and Sitagliptin imparted either ‘additive’ or ‘no effect’ on the activities (inhibition or % killing) of all the four anti-TB drugs, as evident by their lower FICs (Fractional Inhibitory concentrations) and higher bacterial killing in combination. Metformin and Rosiglitazone, however, exerted adverse effect on the Ethambutol (FICs >2.0). All the six anti-HT drugs, namely, Atenolol, Hydrochlorothiazide, Ramipril, Valsartan, Nifedipine and Verapamil exerted either ‘additive’/’synergistic’ or ‘no effect’ on the activities of anti-TB drugs. These findings may help clinicians to select safe and helpful anti-HG or anti-HT drugs for TB patients, if, suffering with diabetes or hypertension like co-morbidities and receiving DOTs (a set regimen for the treatment of TB based on the WHO guidelines).

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference58 articles.

1. Series: Update on tuberculosis” ‐ Tuberculosis and non-communicable diseases: Neglected links and missed opportunities;J Creswell;Eur Respir J,2011

2. The effects of diabetes on tuberculosis treatment outcomes: an updated systematic review and meta-analysis;P Huangfu;Int J Tuber Lung Dis,2019

3. Diabetes Mellitus Among Pulmonary Tuberculosis Patients From 4 Tuberculosis-endemic Countries: The TANDEM Study;Ugarte-GilC;Clin Infect Dis,2020

4. Tuberculosis and Cardiovascular Disease: Linking the Epidemics;MA Huaman;Trop Dis Travel Med Vaccines,2015

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