Abstract
Objective
Maternal vitamin D deficiency is a prevalent public health issue worldwide. While isolated reports from certain cities in China have highlighted the existence of maternal vitamin D deficiency, no nationwide investigation has been conducted on this topic. Therefore, we conducted a meta-analysis and systematic review to examine the prevalence and associated influencing factors of maternal vitamin D deficiency in mainland China. This study aims to provide a theoretical foundation for future prevention and supplementation strategies for maternal vitamin D.
Methods
We retrieved relevant Chinese and English literature on the status of maternal vitamin D deficiency in mainland China from databases such as CNKI, Wanfang Data, VIP, CBM, Web of Science, Google Scholar, and PubMed. The literature search and database construction were conducted until September 8, 2023. Data were extracted and synthesized following PRISMA guidelines.After literature screening and quality assessment, we performed meta-analysis, sensitivity analysis, and identified publication bias using RevMan 5.3 software.
Results
A total of 26 articles were reviewed, involving 128,820 pregnant women. Among them, 108,768 had vitamin D insufficiency or deficiency, resulting in a prevalence of 84% (95% CI: 81%~88%). Subgroup analysis revealed the highest prevalence of vitamin D deficiency or insufficiency among pregnant women in mainland China to be in the northwest region (94%, 95% CI: 94%~95%). Furthermore, the highest prevalence was observed during the winter and spring seasons (80%, 95% CI: 77%~83%) and in the early stages of pregnancy (93%, 95% CI: 90%~95%). Significant statistical differences (P<0.05) were found among these three subgroups. No publication bias was detected, and sensitivity analysis indicated the stability of the meta-analysis outcome.
Conclusion
This study provides evidence of the prevalence of vitamin D deficiency or insufficiency among pregnant women in mainland China. To improve the overall health and well-being of the population, relevant health authorities should develop policies aimed at alleviating this phenomenon.
Publisher
Public Library of Science (PLoS)
Reference57 articles.
1. Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health;ML Tan;Cochrane Database Syst Rev,2020
2. Comparative study on serum 25-hydroxyvitamin D levels in women at different stages of pregnancy.;YM Chen;Zhejiang Preventive Medicine,2013
3. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects;S Christakos;Physiol Rev,2016
4. New aspects of vitamin D metabolism and action—addressing the skin as source and target;D Bikle;Nat Rev Endocrinol,2020
5. Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children.;JL Mansur;Nutrients,2022