Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

Author:

Suri PradeepORCID,Palmer Melody R.ORCID,Tsepilov Yakov A.ORCID,Freidin Maxim B.ORCID,Boer Cindy G.ORCID,Yau Michelle S.,Evans Daniel S.,Gelemanovic AndreaORCID,Bartz Traci M.ORCID,Nethander MariaORCID,Arbeeva Liubov,Karssen LennartORCID,Neogi Tuhina,Campbell ArchieORCID,Mellstrom Dan,Ohlsson Claes,Marshall Lynn M.ORCID,Orwoll Eric,Uitterlinden Andre,Rotter Jerome I.ORCID,Lauc GordanORCID,Psaty Bruce M.,Karlsson Magnus K.,Lane Nancy E.,Jarvik Gail P.ORCID,Polasek Ozren,Hochberg Marc,Jordan Joanne M.,Van Meurs Joyce B. J.,Jackson Rebecca,Nielson Carrie M.,Mitchell Braxton D.,Smith Blair H.ORCID,Hayward Caroline,Smith Nicholas L.,Aulchenko Yurii S.ORCID,Williams Frances M. K.ORCID

Funder

National Heart, Lung, and Blood Institute

European Commissions’ Seventh Framework Programme

National Institute on Aging

National Center for Advancing Translational Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Neurological Disorders and Stroke

Chief Scientist Office of the Scottish Government Health Directorates

Scottish Funding Council

Medical Research Council UK

Wellcome Trust

CDC/Association of Schools of Public Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Swedish Research Council

Swedish Foundation for Strategic Research

ALF/LUA research grant in Gothenburg

Lundberg Foundation

Knut och Alice Wallenbergs Stiftelse (SE)

Torsten Soderberg Foundation

Novo Nordisk UK Research Foundation (GB)

ALF/FoUU research grant in Skane

Herman Järnhardts, Kocks and Österluds Foundations

National Center for Research Resources (US)

National Institutes of Health

Erasmus Medisch Centrum

Erasmus Universiteit Rotterdam

Netherlands Organization for Scientific Research

Netherlands Organization for Health Research and Development

Research Institute for Diseases in the Elderly

Ministerie van Onderwijs, Cultuur en Wetenschap

Ministry for Health, Welfare and Sports

European Commission (DG XII)

Municipality of Rotterdam

Netherlands Organisation of Scientific Research NWO Investments

Genetic Laboratory of the Department of Internal Medicine, Erasmus MC

Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO)

Netherlands Consortium for Healthy Aging (NCHA)

The Croatian Ministry of Science, Education and Sports

European Union framework program 6 EUROSPAN project

Hrvatska Zaklada za Znanost (HR)

Centre for Research Excellence in Personalized Medicine

Centre of Competencies for Integrative Treatment, Prevention and Rehabilitation using TMS

European Community’s Seventh Framework Programme

National Institute for Health Research (NIHR) Clinical Research Facility at Guy’s & St Thomas’ NHS Foundation Trust

NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust

Kings College London

UK Biobank Resource

U.S. Department of Veterans Affairs

Russian Ministry of Science and Education 5-100 Excellence Programme

Publisher

Public Library of Science (PLoS)

Subject

Cancer Research,Genetics(clinical),Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics

Reference78 articles.

1. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study;D Hoy;Annals of the rheumatic diseases,2014

2. Lumbar disc disorders and low-back pain: socioeconomic factors and consequences;JN Katz;The Journal of bone and joint surgery,2006

3. Report of the NIH Task Force on Research Standards for Chronic Low Back Pain;RA Deyo;The spine journal: official journal of the North American Spine Society,2014

4. Prevalence of chronic low back pain: systematic review;RD Meucci;Rev Saude Publica,2015

5. Meta-analysis of the heritability of human traits based on fifty years of twin studies;TJ Polderman;Nat Genet,2015

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