Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection

Author:

Amantana Adams,Chen Yali,Tyavanagimatt Shanthakumar R.,Jones Kevin F.,Jordan Robert,Chinsangaram Jarasvech,Bolken Tove′ C.,Leeds Janet M.,Hruby Dennis E.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference33 articles.

1. Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures;S Duraffour;Antiviral Ther,2007

2. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice;DC Quenelle;Antimicrob Agents and Chemother,2007

3. Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection;E Sbrana;Am J Tropical Med and Hyg,2007

4. Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model;A Nalca;Antiviral Res,2008

5. Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246;J Huggins;Antimicrob Agents and Chemother,2009

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