New Insights into the RNA-Based Mechanism of Action of the Anticancer Drug 5′-Fluorouracil in Eukaryotic Cells

Author:

Mojardín Laura,Botet Javier,Quintales Luis,Moreno Sergio,Salas Margarita

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference62 articles.

1. 5-fluorouracil: mechanisms of action and clinical strategies;DB Longley;Nat Rev Cancer,2003

2. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate;DV Santi;Biochemistry,1974

3. 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity;DW Kufe;J Biol Chem,1981

4. Metabolism and mechanism of action of 5-fluorouracil;WB Parker;Pharmacol Ther,1990

5. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture;RI Glazer;Mol Pharmacol,1982

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