The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

Author:

Ørstavik Øivind,Manfra Ornella,Andressen Kjetil Wessel,Andersen Geir Øystein,Skomedal Tor,Osnes Jan-Bjørn,Levy Finn Olav,Krobert Kurt Allen

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference39 articles.

1. Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan;H Haikala;J Mol Cell Cardiol,1995

2. Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study;P Pollesello;J Biol Chem,1994

3. Mechanisms of the contractile effects of levosimendan in the mammalian heart;P Boknik;J Pharmacol Exp Ther,1997

4. Beneficial effects of the Ca(2+) sensitizer levosimendan in human myocardium;K Brixius;Am J Physiol Heart Circ Physiol,2002

5. Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart;I Edes;Circ Res,1995

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