Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus
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Published:2023-03-28
Issue:3
Volume:19
Page:e1011282
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ISSN:1553-7374
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Container-title:PLOS Pathogens
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language:en
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Short-container-title:PLoS Pathog
Author:
Rosinski Jenna R.ORCID, Raasch Lauren E., Barros Tiburcio Patrick, Breitbach Meghan E., Shepherd Phoenix M., Yamamoto Keisuke, Razo Elaina, Krabbe Nicholas P., Bliss Mason I., Richardson Alexander D., Einwalter Morgan A., Weiler Andrea M., Sneed Emily L., Fuchs Kerri B., Zeng Xiankun, Noguchi Kevin K., Morgan Terry K., Alberts Alexandra J., Antony Kathleen M., Kabakov Sabrina, Ausderau Karla K., Bohm Ellie K., Pritchard Julia C., Spanton Rachel V., Ver Hoove James N., Kim Charlene B. Y., Nork T. Michael, Katz Alex W., Rasmussen Carol A., Hartman Amy, Mejia Andres, Basu Puja, Simmons Heather A., Eickhoff Jens C., Friedrich Thomas C., Aliota Matthew T., Mohr Emma L., Dudley Dawn M., O’Connor David H., Newman Christina M.
Abstract
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.
Funder
National Institute of Health National Institute of Allergy and Infectious Diseases
Publisher
Public Library of Science (PLoS)
Subject
Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology
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