Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Author:

Lampa Michael,Arlt Heike,He Timothy,Ospina Beatriz,Reeves Jason,Zhang Bailin,Murtie Joshua,Deng Gejing,Barberis Claude,Hoffmann Dietmar,Cheng Hong,Pollard Jack,Winter Christopher,Richon Victoria,Garcia-Escheverria Carlos,Adrian Francisco,Wiederschain Dmitri,Srinivasan LakshmiORCID

Funder

Sanofi

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference54 articles.

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3. Understanding the Warburg effect: the metabolic requirements of cell proliferation;MG Vander Heiden;Science,2009

4. Glutamine addiction: a new therapeutic target in cancer;DR Wise;Trends Biochem Sci,2010

5. Relevance of glutamine metabolism to tumor cell growth;MA Medina;Molecular and cellular biochemistry,1992

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