In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy

Author:

Wang Jianxun,Chandrasekhar Vasanth,Abbadessa Giovanni,Yu Yi,Schwartz Brian,Kontaridis Maria I.ORCID

Funder

Beth Israel Deaconess Medical Center

Arqule

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference23 articles.

1. Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway;WE Tidyman;Expert Rev Mol Med,2008

2. HRAS and the Costello syndrome;KA Rauen;Clin Genet,2007

3. Noonan syndrome and related disorders: genetics and pathogenesis;M Tartaglia;Annual review of genomics and human genetics,2005

4. The Leopard (multiple lentigines) syndrome revisited;RJ Gorlin;Birth Defects Orig Artic Ser,1971

5. PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes;T Ogata;Pediatr Endocrinol Rev,2005

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