Abstract
Background
Mechanical insufflation-exsufflation (MI-E) facilitates extubation. However, its potential to reduce the duration of ventilator use remains unclear. Therefore, the present study investigated whether the use of MI-E shortened the duration of mechanical ventilation in patients with high sputum retention.
Methods
A randomized open-label trial was conducted at a single intensive care unit (ICU) in Japan between November 2017 and June 2019. Ventilated subjects requiring suctioning at least once every hour due to sputum retention were randomly assigned to the MI-E group or conventional care group. The primary endpoint was the number of ventilator-free days on day 28. Secondary endpoints were ventilator days in surviving subjects, the length of ICU stay, and mortality and tracheostomy rates among survivors.
Results
Forty-eight subjects (81% males) with a median age of 72 years (interquartile range [IQR], 65–85 years) were enrolled. There were 27 subjects in the MI-E group and 21 in the control group. The median number of ventilator-free days was 21 (IQR, 13–24) and 18, respectively (IQR, 0–23) (P = .38). No significant differences were observed in the ICU length of stay (median, 10 days (IQR, 7–12) vs 12 days (IQR, 6–15); P = .31), mortality rate (19% vs 15%; odds ratio [OR], 1.36 [0.28–6.50]; P = .69), or tracheostomy rate among survivors (14% vs 28%; OR, 0.40 [0.08–1.91]; P = .25).
Conclusion
In ventilated subjects in the ICU with high sputum retention, the use of MI-E did not significantly increase the number of ventilator-free days over that with conventional care.
Publisher
Public Library of Science (PLoS)
Reference26 articles.
1. Clinical review: intensive care unit acquired weakness;G Hermans;Crit Care,2015
2. Mucociliary clearance is impaired in acutely ill patients;NK Nakagawa;Chest,2005
3. Neurologic status, cough, secretions, and extubation outcomes;A Salam;Intensive Care Med,2004
4. Cough augmentation techniques for extubation or weaning critically ill patients from mechanical ventilation;L Rose;Cochrane Database Syst Rev,2017
5. Cough peak flows and extubation outcomes;M Smina;Chest,2003
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献