Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity

Author:

Chauvot de Beauchêne Isaure,Allain Ariane,Panel Nicolas,Laine Elodie,Trouvé Alain,Dubreuil Patrice,Tchertanov Luba

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference117 articles.

1. The biology of stem cell factor and its receptor C-kit;LK Ashman;Int J Biochem Cell Biol,1999

2. Early signaling pathways activated by c-Kit in hematopoietic cells;D Linnekin;Int J Biochem Cell Biol,1999

3. Structure and regulation of Kit protein-tyrosine kinase - The stem cell factor receptor;R Roskoski;Biochemical and Biophysical Research Communications,2005

4. c-Kit–a hematopoietic cell essential receptor tyrosine kinase;CE Edling;Int J Biochem Cell Biol,2007

5. Normal and oncogenic forms of the receptor tyrosine kinase kit;J Lennartsson;Stem Cells,2005

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