Biomechanical study on the effect of atherosclerosis on the vulnerability of thoracic aorta, and it’s role in the development of traumatic aorta injury

Author:

Pauka Dénes,Poór Viktor Soma,Maróti PéterORCID,Told RolandORCID,Tóth DénesORCID,Tornóczky Tamás,Molnár Tamás F.,Simon GáborORCID

Abstract

Traumatic aorta injury (TAI) is the second most common traumatic cause of death preceded only by head injuries, being responsible for 5% to 30% of all mortalities in high-speed deceleration injuries. Multiple external factors might play a role such as impact speed, impact direction, occupant location, and presence or lack of restraining safety mechanism. Apart from these external factors, also human biological factors can influence its development. Based on the data of scientific literature, age clearly plays a role in suffering TAI, but the role of atherosclerosis–as a disease affecting the structure of the aorta–is unknown. Biomechanical properties of tissue samples of 104 aorta specimens removed during the autopsy from the posterior (Group ‘A’) and lateral wall (Group ‘B’) of descending aorta were analyzed. Specimens were examined by a Zwick/Roell Z5.0 biaxial tester. The Young’s modulus (E (MPa)) was calculated using a linear regression procedure where the base of the elongation was the parallel length of the sample, the achieved maximal force (Fmax (N)), the elongation at the time of Fmax (Lmax (mm)), the force at the beginning of rupture (Fbreak (N)), the elongation at the time of Fbreak (Lbreak (mm)) were registered. Specimens were categorized based on macroscopic and microscopic appearance. In the posterior (A) samples the difference between Lbreak (p<0.001) and Lmax (p<0.001) was significant between the macroscopic group. Lbreak (p = 0.009) and Lmax (p = 0.003) showed similar pattern in the lateral (B) samples. Comparing the histological groups by the measured parameters (Fmax, Lmax, Fbreak, Lbreak) showed a significant difference in the means (p<0.001, p = 0.003, p<0.001 respectively). The study demonstrated that atherosclerosis decreases the resistance of the aorta. The rupture occurs at lower force (Fmax and Fbreak), and at shorter elongation (Lmax and Lbreak) in case of the presence of atherosclerosis. This effect is most substantial if calcification is present: the resistance of aorta affected by calcification is only two-thirds on average compared to aorta affected by the early phase of atherosclerosis. This phenomenon can be clearly explained by the weakening structure of the tunica intima.

Funder

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference41 articles.

1. No Title [Internet];WHO;Road traffic injuries

2. Optimal management of traumatic aortic injury;R Fattori;Eur J Vasc Endovasc Surg Off J Eur Soc Vasc Surg,2009

3. Thoracic Trauma: Aortic Injuries.;A Monga;Semin Intervent Radiol.,2021

4. Rupture of the aorta following road traffic accidents in the United Kingdom 1992–1999. The results of the co-operative crash injury study;D Richens;Eur J cardio-thoracic Surg Off J Eur Assoc Cardio-thoracic Surg.,2003

5. Blunt Traumatic Aortic Injury: 10-Year Single-Center Experience.;AC Topcu;Aorta (Stamford, Conn).,2020

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