A Perspective on the Emergence of Sialic Acids as Potent Determinants AffectingLeishmaniaBiology

Author:

Ghoshal Angana12,Mandal Chitra1

Affiliation:

1. Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata 700032, India

2. Department of Zoology, Triveni Devi Bhalotia College, Raniganj, Burdwan 713347, India

Abstract

Leishmaniasis caused byLeishmania sp. has a wide range of manifestations from cutaneous to the deadly visceral form. They shuttle between the invertebrate and vertebrate hosts as promastigotes and amastigotes having adaptations for subverting host immune responses. Parasite-specific glycoconjugates have served as important determinants influencing parasite recognition, internalization, differentiation, multiplication, and virulence. Despite the steady progress in the field of parasite glycobiology, sialobiology has been a less traversed domain of research in leishmaniasis. The present paper focuses on identification, characterization, and differential distribution of sialoglycotope having the linkage-specific 9-O-acetylated sialic acid in promastigotes of differentLeishmania sp. causing different clinical ramifications emphasizing possible role of these sialoglycotopes in infectivity, virulence, nitric oxide resistance, and host modulation inLeishmania spp. asserting them to be important molecules influencing parasite biology.

Publisher

Hindawi Limited

Subject

General Economics, Econometrics and Finance

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