Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018-Reference-Cited by-同舟云学术

Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

Published:2019-03-07 Issue:10 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Eyre David W¹²,Town Katy³,Street Teresa¹,Barker Leanne¹,Sanderson Nicholas¹,Cole Michelle J³,Mohammed Hamish³,Pitt Rachel³,Gobin Maya³,Irish Charles³,Gardiner Daniel³,Sedgwick James³,Beck Charles³,Saunders John³,Turbitt Deborah³,Cook Clare³,Phin Nick³,Nathan Bavithra⁴³,Horner Paddy⁴⁵³,Fifer Helen⁴³

Affiliation:

1. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

2. Big Data Institute, University of Oxford, Oxford, United Kingdom

3. National Incident Management Team, Public Health England, London, United Kingdom

4. These authors contributed equally to this work

5. Population Health Sciences, University of Bristol, Bristol, United Kingdom

Abstract

We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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