Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018-Reference-Cited by-同舟云学术

Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

Published:2018-07-05 Issue:27 Volume:23 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Eyre David W¹²,Sanderson Nicholas D¹,Lord Emily³,Regisford-Reimmer Natasha³,Chau Kevin¹,Barker Leanne¹,Morgan Markus³,Newnham Robert³,Golparian Daniel⁴,Unemo Magnus⁴,Crook Derrick W⁵⁶¹,Peto Tim EA⁵¹,Hughes Gwenda⁶,Cole Michelle J⁶,Fifer Helen⁶,Edwards Anne⁷³,Andersson Monique I⁷³

Affiliation:

1. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

2. Big Data Institute, University of Oxford, Oxford, United Kingdom

3. Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

4. WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Örebro University Hospital, Örebro, Sweden

5. National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom

6. National Infection Service, Public Health England, Colindale, United Kingdom

7. The authors contributed equally to this work

Abstract

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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