Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak

Author:

Nhan Le Nguyen Thanh1,Hong Nguyen Thi Thu2,Nhu Le Nguyen Truc2,Nguyet Lam Anh2,Ny Nguyen Thi Han2,Thanh Tran Tan2,Han Do Duong Kim2,Van Hoang Minh Tu2,Thwaites C Louise32,Hien Tran Tinh32,Qui Phan Tu4,Quang Pham Van1,Minh Ngo Ngoc Quang1,van Doorn H. Rogier32,Khanh Truong Huu1,Chau Nguyen Van Vinh4,Thwaites Guy32,Hung Nguyen Thanh1,Tan Le Van2

Affiliation:

1. Children’s Hospital 1, Ho Chi Minh City, Vietnam

2. Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

4. Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Abstract

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011–12 among susceptible young children raises concern of another impending severe outbreak.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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