Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons-Reference-Cited by-同舟云学术

Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

Published:2019-01-17 Issue:3 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Gubareva Larisa V¹^ORCID,Mishin Vasiliy P¹,Patel Mira C²¹,Chesnokov Anton¹,Nguyen Ha T²¹,De La Cruz Juan²¹,Spencer Sarah¹,Campbell Angela P¹,Sinner Mallory³,Reid Heather³,Garten Rebecca¹,Katz Jackie M¹,Fry Alicia M¹,Barnes John¹,Wentworth David E¹

Affiliation:

1. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, United States of America

2. Battelle Memorial Institute, Atlanta, United States of America

3. Illinois Department of Public Health, Springfield, United States of America

Abstract

The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4–10-fold reduced susceptibility to baloxavir.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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