Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021

Author:

Mazagatos Clara1,Monge Susana2,Olmedo Carmen3,Vega Lorena1,Gallego Pilar1,Martín-Merino Elisa4,Sierra María José2,Limia Aurora3,Larrauri Amparo1,

Affiliation:

1. National Centre for Epidemiology, Institute of Health Carlos III, Madrid, Spain, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, Madrid, Spain

2. Centre for the Coordination of Alerts and Health Emergencies, General Directorate of Public Health, Ministry of Health, Madrid, Spain

3. Vaccines Division, General Directorate of Public Health, Ministry of Health, Madrid, Spain

4. Spanish Agency of Medicines and Medical Devices-AEMPS, Madrid, Spain

Abstract

Residents in long-term care facilities (LTCF) experienced a large morbidity and mortality during the COVID-19 pandemic in Spain and were prioritised for early COVID-19 vaccination. We used the screening method and population-based data sources to obtain estimates of mRNA COVID-19 vaccine effectiveness for elderly LTCF residents. The estimates were 71% (95% CI: 56–82%), 88% (95% CI: 75–95%), and 97% (95% CI: 92-99%), against SARS-CoV-2 infections (symptomatic and asymptomatic), and COVID-19 hospitalisations and deaths, respectively.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference14 articles.

1. Ministerio de Sanidad, Gobierno de España. Informe de Gestión Integral de la Vacunación COVID-19, Fecha del informe 12 de abril de 2021. [COVID-19 Vaccination Management Report, Ministry of Health, Government of Spain]. Madrid: Ministerio de Sanidad; 2021. Spanish. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Informe_GIV_comunicacion_20210412.pdf

2. Estimation of vaccine effectiveness using the screening method.;Farrington;Int J Epidemiol,1993

3. Application of the screening method to monitor influenza vaccine effectiveness among the elderly in Germany.;Remschmidt;BMC Infect Dis,2015

4. Exploring the risk of severe outcomes and the role of seasonal influenza vaccination in pregnant women hospitalized with confirmed influenza, Spain, 2010/11-2015/16.;Mazagatos;PLoS One,2018

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