Shorter serial intervals in SARS-CoV-2 cases with Omicron BA.1 variant compared with Delta variant, the Netherlands, 13 to 26 December 2021

Author:

Backer Jantien A1ORCID,Eggink Dirk1ORCID,Andeweg Stijn P1ORCID,Veldhuijzen Irene K1ORCID,van Maarseveen Noortje23,Vermaas Klaas3ORCID,Vlaemynck Boris4,Schepers Raf4,van den Hof Susan1ORCID,Reusken Chantal BEM1ORCID,Wallinga Jacco51ORCID

Affiliation:

1. Center for Infectious Disease Control, WHO COVID-19 reference laboratory, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

2. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands

3. Saltro Diagnostic Center for Primary Care, Utrecht, The Netherlands

4. SYNLAB, Heppignies, Belgium

5. Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands

Abstract

The SARS-CoV-2 Omicron variant has a growth advantage over the Delta variant because of higher transmissibility, immune evasion or shorter serial interval. Using S gene target failure (SGTF) as indication for Omicron BA.1, we identified 908 SGTF and 1,621 non-SGTF serial intervals in the same period. Within households, the mean serial interval for SGTF cases was 0.2–0.6 days shorter than for non-SGTF cases. This suggests that the growth advantage of Omicron is partly due to a shorter serial interval.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference16 articles.

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2. Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark.;Ito;J Med Virol,2021

3. SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.;Cele;medRxiv,2021

4. Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022.;Eggink;Euro Surveill,2022

5. Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies.;Wilhelm;medRxiv,2021

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