High attack rate in a large care home outbreak of SARS-CoV-2 BA.2.86, East of England, August 2023

Author:

Reeve Lucy1,Tessier Elise2ORCID,Trindall Amy1,Abdul Aziz Nurin Iwani Binti2,Andrews Nick3,Futschik Matthias4,Rayner Jessica5,Didier’Serre Alexis5,Hams Rebecca51,Groves Natalie6,Gallagher Eileen6,Graham Rachael6,Kele Beatrix7,Hoschler Katja7,Fowler Tom4,Blandford Edward4,Mahgoub Hamid5,Hoffmann Jorg5,Ramsay Mary3,Dabrera Gavin2,Chand Meera7,Zambon Maria7,Sharp Ashley1,Heinsbroek Ellen81,Lopez Bernal Jamie82ORCID

Affiliation:

1. Field Service East of England, UK Health Security Agency, Cambridge, United Kingdom

2. COVID-19 Vaccines and Epidemiology Division, UK Health Security Agency, London, United Kingdom

3. Immunisations and Countermeasures Division, UK Health Security Agency, London, United Kingdom

4. Public Health and Clinical Oversight, COVID-19 Testing, Clinical and Public Health Division, UK Health Security Agency, London, United Kingdom

5. East of England Health Protection Team, UK Health Security Agency, Cambridge, United Kingdom

6. TB, Acute Respiratory, Zoonoses, Emerging infection, and Travel Health Division, UK Health Security Agency, London, United Kingdom

7. Respiratory Virus Unit, UK Health Security Agency, London, United Kingdom

8. These authors contributed equally to this work and share last authorship.

Abstract

We investigated an outbreak of SARS-CoV-2 variant BA.2.86 in an East of England care home. We identified 45 infections (33 residents, 12 staff), among 38 residents and 66 staff. Twenty-nine of 43 PCR swabs were sequenced, all of which were variant BA.2.86. The attack rate among residents was 87%, 19 were symptomatic, and one was hospitalised. Twenty-four days after the outbreak started, no cases were still unwell. Among the 33 resident cases, 29 had been vaccinated 4 months earlier.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference17 articles.

1. UK Health Security Agency (UKHSA). Risk assessment for SARS-CoV-2 variant V-23AUG-01 (BA.2.86) 2023. Updated 1 September 2023. London: UKHSA; 2023. Available from: https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-of-concern-variant-risk-assessments/risk-assessment-for-sars-cov-2-variant-v-23aug-01-or-ba286

2. UK Health Security Agency (UKHSA). Situational assessment for SARS-CoV-2 variant V-23AUG-01 (BA.2.86) 2023. Updated 1 September 2023. London: UKHSA; 2023. Available from: https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-of-concern-variant-risk-assessments/situational-assessment-for-sars-cov-2-variant-v-23aug-01-ba286

3. First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023.;Rasmussen;Euro Surveill,2023

4. 2nd-Generation BA.2 Saltation Lineage, >30 spike mutations (3 seq, 2 countries, Aug 14) #2183. Github; 2023. Available from: https://github.com/cov-lineages/pango-designation/issues/2183

5. UK Health Security Agency (UKHSA). COVID-19 supplement to the infection prevention and control resource for adult social care. Updated 25 August 2023. London: UKHSA; 2023. Available from: https://www.gov.uk/government/publications/infection-prevention-and-control-in-adult-social-care-covid-19-supplement/covid-19-supplement-to-the-infection-prevention-and-control-resource-for-adult-social-care

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