Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020-Reference-Cited by-同舟云学术

Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

Published:2020-03-19 Issue:11 Volume:25 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Haveri Anu¹,Smura Teemu²,Kuivanen Suvi²,Österlund Pamela¹,Hepojoki Jussi³²,Ikonen Niina¹,Pitkäpaasi Marjaana¹,Blomqvist Soile¹,Rönkkö Esa¹,Kantele Anu⁴,Strandin Tomas²,Kallio-Kokko Hannimari⁵,Mannonen Laura⁵,Lappalainen Maija⁵,Broas Markku⁶,Jiang Miao⁷¹,Siira Lotta¹,Salminen Mika¹,Puumalainen Taneli¹,Sane Jussi¹,Melin Merit¹,Vapalahti Olli⁵²,Savolainen-Kopra Carita¹

Affiliation:

1. Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland

2. University of Helsinki, Medicum, Department of Virology, Helsinki, Finland

3. Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland

4. Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland

5. Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland

6. Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland

7. Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland

Abstract

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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