Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe-Reference-Cited by-同舟云学术

Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe

Published:2020-04-02 Issue:13 Volume:25 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Stefanelli Paola¹,Faggioni Giovanni²,Lo Presti Alessandra¹,Fiore Stefano³¹,Marchi Antonella³¹,Benedetti Eleonora³¹,Fabiani Concetta³¹,Anselmo Anna²,Ciammaruconi Andrea²,Fortunato Antonella²,De Santis Riccardo²,Fillo Silvia²,Capobianchi Maria Rosaria⁴,Gismondo Maria Rita⁵,Ciervo Alessandra¹,Rezza Giovanni¹,Castrucci Maria Rita¹,Lista Florigio²,

Affiliation:

1. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

2. Scientific Department Army Medical Center, Rome, Italy

3. These authors contributed equally to the work

4. Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

5. Clinical Microbiology, Virology and Bioemergency, L. Sacco University Hospital, Milan, Italy

Abstract

Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient’s sequence clustered with sequences from Germany while the tourist’s sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients’ sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference8 articles.

1. Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020.;Wu;Euro Surveill,2020

2. Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data.;Kearse;Bioinformatics,2012

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