Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe

Author:

Stefanelli Paola1,Faggioni Giovanni2,Lo Presti Alessandra1,Fiore Stefano31,Marchi Antonella31,Benedetti Eleonora31,Fabiani Concetta31,Anselmo Anna2,Ciammaruconi Andrea2,Fortunato Antonella2,De Santis Riccardo2,Fillo Silvia2,Capobianchi Maria Rosaria4,Gismondo Maria Rita5,Ciervo Alessandra1,Rezza Giovanni1,Castrucci Maria Rita1,Lista Florigio2,

Affiliation:

1. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

2. Scientific Department Army Medical Center, Rome, Italy

3. These authors contributed equally to the work

4. Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

5. Clinical Microbiology, Virology and Bioemergency, L. Sacco University Hospital, Milan, Italy

Abstract

Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient’s sequence clustered with sequences from Germany while the tourist’s sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients’ sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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