Early COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023

Author:

van Werkhoven C Henri12,Valk Anne-Wil2,Smagge Bente2,de Melker Hester E2,Knol Mirjam J2,Hahné Susan JM2,van den Hof Susan2,de Gier Brechje2

Affiliation:

1. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

2. Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

Abstract

We present early vaccine effectiveness (VE) estimates of the 2023 seasonal COVID-19 XBB.1.5 vaccine against COVID-19 hospitalisation and admission to an intensive care unit (ICU) in previously vaccinated adults ≥ 60 years in the Netherlands. We compared vaccination status of 2,050 hospitalisations including 92 ICU admissions with age group-, sex-, region- and date-specific population vaccination coverage between 9 October and 5 December 2023. VE against hospitalisation was 70.7% (95% CI: 66.6–74.3), VE against ICU admission was 73.3% (95% CI: 42.2–87.6).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference10 articles.

1. National Institute for Public Health and the Environment (RIVM). Deelname COVID-19-vaccinatie in Nederland (19 december 2023) [Uptake of COVID-19 vaccination in the Netherlands (19 December 2023)]. Bilthoven: RIVM; 2023. [Dutch]. Available from: https://www.rivm.nl/corona/actueel/vaccinatiecijfers/update-deelname-covid-19-vaccinatie-in-nederland

2. Government of the Netherlands. Coronavirus Dashboard. Virus particles in wastewater. The Hague: Rijksoverheid. [Accessed: 20 Dec 2023]. Available from: https://coronadashboard.government.nl/landelijk/rioolwater

3. Government of the Netherlands. Coronavirus Dashboard. View on the hospitals. The Hague: Rijksoverheid. [Accessed: 12 Dec 2023]. Available from: https://coronadashboard.government.nl/landelijk/ziekenhuizen-in-beeld

4. Information bias of vaccine effectiveness estimation due to informed consent for national registration of COVID-19 vaccination: estimation and correction using a data augmentation model.;Van Werkhoven;medRxiv,2023

5. National Institute for Public Health and the Environment (RIVM). Uitvoeringsrichtlijn COVID-19-vaccinatie, versie 5.1 (8 december 2023). [COVID-19 guideline version 5.1 (8 December 2023)]. Bilthoven: RIVM; 2023. Dutch. Available from: https://lci.rivm.nl/richtlijnen/covid-19-vaccinatie

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