Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021-Reference-Cited by-同舟云学术

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Published:2021-02-11 Issue:6 Volume:26 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Abu Jabal Kamal¹²³,Ben-Amram Hila²³,Beiruti Karine³,Batheesh Yunis³,Sussan Christian³,Zarka Salman¹³,Edelstein Michael¹³^ORCID

Affiliation:

1. Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

2. These authors contributed equally to this article and share first authorship

3. Ziv Medical Centre, Safed, Israel

Abstract

The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

1. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine.;Baden;N Engl J Med,2021

2. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine.;Polack;N Engl J Med,2020

3. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.;Ramasamy;Lancet,2021

4. Black, Asian and Minority Ethnic groups in England are at increased risk of death from COVID-19: indirect standardisation of NHS mortality data.;Aldridge;Wellcome Open Res,2020

Cited by 255 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. COVID-19 Breakthrough Infections Among People With HIV: A Statewide Cohort Analysis;JAIDS Journal of Acquired Immune Deficiency Syndromes;2024-10-01

2. Factors influencing antibody response after COVID-19 recombinant protein vaccination in adults: A cross-sectional observational study, in Chongqing, China;Human Vaccines & Immunotherapeutics;2024-08-22

3. Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination;iScience;2024-08

4. Comparative analysis of eleven SARS-CoV-2 immunoassays and neutralisation data: time to enhance standardisation and correlation of protection;Infectious Diseases;2024-07-24

5. Effectiveness of different booster vaccine combinations against SARS-CoV-2 during a six-month follow-up in Mexico and Argentina;Frontiers in Immunology;2024-05-14