The Early Use of Selective Hemoadsorption Based on a Hyper-Crosslinked Styrene-Divinylbenzene Copolymer in Patients with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury (Multicenter Randomized Clinical Trial)-Reference-Cited by-同舟云学术

The Early Use of Selective Hemoadsorption Based on a Hyper-Crosslinked Styrene-Divinylbenzene Copolymer in Patients with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury (Multicenter Randomized Clinical Trial)

Published:2022-12-19 Issue:6 Volume:18 Page:22-29
ISSN:2411-7110
Container-title:General Reanimatology
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Author:

Masolitin S. V.¹,Protsenko D. N.²,Tyurin I. N.³,Magomedov M. A.⁴,Kim T. G.⁵,Grishina L. A.⁵,Bykov A. O.²,Gelfand Е. B.⁶,Ignatenko O. V.⁷

Affiliation:

1. N.I. Pirogov City Clinical Hospital № 1, Moscow City Health Department

2. Moscow Multispecialized Clinical Center Kommunarka, Moscow City Health Department; N.I. Pirogov Russian National Medical Research University, Ministry of Health of Russia

3. Moscow Multispecialized Clinical Center Kommunarka, Moscow City Health Department

4. N.I. Pirogov City Clinical Hospital № 1, Moscow Department of Health; N.I. Pirogov Russian National Medical Research University, Ministry of Health of Russia

5. N.I. Pirogov City Clinical Hospital № 1, Moscow Department of Health

6. N.I. Pirogov Russian National Medical Research University, Ministry of Health of Russia

7. N.I. Pirogov Russian National Medical Research University, Ministry of Health of Russia; Yudin City Clinical Hospital, Moscow City Health Department

Abstract

Rhabdomyolysis (RM) is a clinical and laboratory syndrome with the underlying destruction of myocytes and the release of intracellular debris into the systemic circulation. In more than 55% of cases, RM is complicated by acute kidney injury (AKI), which necessitates various methods of extracorporeal detoxification and currently is a controversial issue.Aim: to improve the results of treatment of patients with RM of toxic origin complicated by AKI by using early selective hemoadsorption (SH).Material and methods. The study included 36 patients divided into 2 groups. Group 1 included 24 patients who received standard therapy and hemodiafiltration (HDF) as a life-saving intervention. Group 2 comprised 12 patients who underwent early SH to prevent the progression of AKI. We performed a comparative analysis of clinical and laboratory parameters and treatment outcomes in the groups.Results. The use of SH was associated with reduced level of myoglobin on day5 of therapy from 384.1 to 112.4 gg/l (70.7%) vs 335.15 to 219.1 gg/l (34.6%) reduction in the conservative therapy group. By day 7, this parameter was 18.8 (95.1%) and 142.4 (57.5%), respectively (7=0.012). The level of cystatin-C decreased on day 5 from 17.3 to 3.2 mg/l (81.5%) in group 2 and from 14.9 to 11.7 mg/l (21.5%) in group 1. By day 7, this parameter decreased to 2.5 (85.6%) and 14.1 (5.3%) mg/l, respectively (7=0.001). The length of ICU stay in group 2 was 7 (6; 9) days, while in the conservative therapy group it was 12 (7; 13) days (7=0.04). The hospital stay was 12 (10; 16) and 22 (14,5; 24,5) days, respectively (7=0.028).Conclusion. The early use of SH in the intensive therapy helped decrease the levels of markers of endogenous intoxication, AKI severity, improve the filtration capacity of the kidneys, and reduced the length of stay in the ICU and hospital.

Publisher

FSBI SRIGR RAMS

Subject

Critical Care and Intensive Care Medicine

Reference33 articles.

1. Kolovou G., Cokkinos P, Bilianou H., Kolovou V, Katsiki N., Mavrogeni S. Non-traumatic and non-drug-induced rhabdomyolysis. Arch Med Sci Atheroscler Dis. 2019; 4: e252-e263. DOI: 10.5114/amsad.2019.90152. PMID: 32368681.

2. ChavezL.O., LeonM., EinavS., Varon J. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit Care. 2016; 20 (1): 135. DOI: 10.1186/s13054-016-1314-5. PMID: 27301374.

3. Safari S., Yousefifard M., Hashemi B., Baratloo A., Forouzanfar M.M., Rahmati F., Motamedi M., Najafi I. The value of serum creatine kinase in predicting the risk of rhabdomyolysis-induced acute kidney injury: a systematic review and meta-analysis. Clin Exp Nephrol. 2016; 20 (2): 153-161. DOI: 10.1007/s10157-015-1204-1. PMID: 26801932.

4. Petejova N., Martinek A. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit Care. 2014; 18 (3): 224. DOI: 10.1186/cc13897. PMID: 25043142.

5. KhoroshilovS.E., NikulinA.V. Pathogenesis, diagnosis and efferent treatment of rhabdomyolysis complicated by acute renal failure. Tver Medical Journal/Tverskoy Meditsinskiy Zhurnal. 2017; 5: 45-51. (in Russ.).

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