Cell therapy for cartilage repair-Reference-Cited by-同舟云学术

Cell therapy for cartilage repair

Published:2021-08-23 Issue:4 Volume:5 Page:575-589
ISSN:2397-8554
Container-title:Emerging Topics in Life Sciences
language:en
Short-container-title:

Author:

Hulme Charlotte H.¹²^ORCID,Perry Jade¹²,McCarthy Helen S.¹²,Wright Karina T.¹²,Snow Martyn³,Mennan Claire¹²,Roberts Sally¹²

Affiliation:

1. School of Pharmacy and Bioengineering, Keele University, Keele, Staffordshire, U.K.

2. Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, U.K.

3. The Royal Orthopaedic Hospital, Birmingham, U.K.

Abstract

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations, which were designed for pharmaceutical agents, to living cells. In addition, using autologous cells as the therapeutic agent brings additional costs and logistical challenges compared with using allogeneic cells. The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord. This review discusses some of their biology and pre-clinical studies before describing the most pertinent clinical trials in this area.

Publisher

Portland Press Ltd.

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://portlandpress.com/emergtoplifesci/article-pdf/5/4/575/922900/etls-2021-0015c.pdf

Reference97 articles.

1. Of the structure and diseases of articulating cartilages;Philos. Trans. R. Soc. Lond.,1743

2. Factors affecting progression of knee cartilage defects in normal subjects over 2 years;Rheumatology,2006

3. Registry, N.J. (2020) 17th Annual Report 2020https://reports.njrcentre.org.uk/Portals/0/PDFdownloads/NJR%2017th%20Annual%20Report%202020.pdf

4. OARSI White Paper- OA as a Serious Disease | Osteoarthritis research society international (oarsi)

5. Microfracture versus autologous chondrocyte implantation for articular cartilage lesions in the knee: a systematic review of 5-year outcomes;Am. J. Sports Med.,2018

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