PCR in forensic genetics

Author:

Morling Niels1

Affiliation:

1. Department of Forensic Genetics, Faculty of Health Sciences, University of Copenhagen, 11 Frederik V's Vej, 2100 Copenhagen, Denmark

Abstract

Since the introduction in the mid-1980s of analyses of minisatellites for DNA analyses, a revolution has taken place in forensic genetics. The subsequent invention of the PCR made it possible to develop forensic genetics tools that allow both very informative routine investigations and still more and more advanced, special investigations in cases concerning crime, paternity, relationship, disaster victim identification etc. The present review gives an update on the use of DNA investigations in forensic genetics.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Reference13 articles.

1. Individual-specific ‘fingerprints’ of human DNA;Jeffreys;Nature,1985

2. Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction;Mullis;Cold Spring Harbor Symp. Quant. Biol.,1986

3. Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus;Gyllensten;Proc. Natl. Acad. Sci. U.S.A.,1988

4. Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE;Budowle;Am. J. Hum. Genet.,1991

5. Automated DNA profiling employing multiplex amplification of short tandem repeat loci;Kimpton;PCR Methods Appl.,1993

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