The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression-Reference-Cited by-同舟云学术

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression

Published:2005-06-01 Issue:3 Volume:33 Page:499-501
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Smith R.W.P.¹,Malik P.¹,Clements J.B.¹

Affiliation:

1. Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, U.K.

Abstract

The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/33/3/499/509716/bst0330499.pdf

Reference55 articles.

1. Herpes simplex virus type 1 ICP27 is an essential regulatory protein

2. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient

3. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection

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