BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer-Reference-Cited by-同舟云学术

BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer

Published:2012-07-20 Issue:4 Volume:40 Page:768-772
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Tammaro Claudia¹,Raponi Michela¹,Wilson David I.¹,Baralle Diana¹

Affiliation:

1. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Institute of Developmental Sciences Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, U.K.

Abstract

BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary epithelial cells. The importance of this difference in the pathogenesis of breast cancer has yet to be determined. Developing an understanding of the impact of BRCA1 isoform ratio changes on cell phenotype will be of value in breast cancer and may offer therapeutic options. In the present paper, we describe the splicing isoforms of BRCA1 exon 11, their possible role in cancer biology and the importance of maintaining a balanced ratio.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/40/4/768/485464/bst0400768.pdf

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