Affiliation:
1. MRC Toxicology Unit, Hodgkin Building, P.O. Box 138, Lancaster Rd., Leicester LE1 9HN, U.K.
Abstract
Apoptosis induced in primary hepatocytes by transforming growth factor β1 and staurosporine produces chromatin condensation, DNA cleavage as detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonylvalinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
78 articles.
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