The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminals in vivo-Reference-Cited by-同舟云学术

The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminals in vivo

Published:2010-03-22 Issue:2 Volume:38 Page:525-528
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Bauer Claudia S.¹,Rahman Wahida¹,Tran-Van-Minh Alexandra¹,Lujan Rafael²,Dickenson Anthony H.¹,Dolphin Annette C.¹

Affiliation:

1. Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, U.K.

2. Departamento Ciencias Medicas, Universidad de Castilla-La Mancha, 02006 Albacete, Spain

Abstract

Neuropathic pain is caused by lesion or dysfunction of the peripheral sensory nervous system. Up-regulation of the voltage-gated Ca2+ channel subunit α2δ-1 in DRG (dorsal root ganglion) neurons and the spinal cord correlates with the onset of neuropathic pain symptoms such as allodynia in several animal models of neuropathic pain. The clinically important anti-allodynic drugs gabapentin and pregabalin are α2δ-1 ligands, but how these drugs alleviate neuropathic pain is poorly understood. In the present paper, we review recent advances in our understanding of their molecular mechanisms.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/38/2/525/516910/bst0380525.pdf

Reference24 articles.

1. The epidemiology of chronic pain of predominantly neuropathic origin: results from a general population survey;Torrance;J. Pain,2006

2. From nociception to pain perception: imaging the spinal and supraspinal pathways;Brooks;J. Anat.,2005

3. Cell signaling and the genesis of neuropathic pain;Ji;Sci. STKE,2004

4. The healthcare costs of diabetic peripheral neuropathy in the UK;Gordois;Diabetic Foot,2003

5. Functional biology of the α2δ subunits of voltage-gated calcium channels;Davies;Trends Pharmacol. Sci.,2007

Cited by 82 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief;ACS Pharmacology & Translational Science;2024-06-06

2. The role of voltage-gated calcium channel α2δ-1 in the occurrence and development in myofascial orofacial pain;BMC Oral Health;2024-05-12

3. A peptidomimetic modulator of the Ca _V 2.2 N-type calcium channel for chronic pain;Proceedings of the National Academy of Sciences;2023-11-16

4. Mechanism of Analgesia by Gabapentinoid Drugs: Involvement of Modulation of Synaptogenesis and Trafficking of Glutamate-Gated Ion Channels;Journal of Pharmacology and Experimental Therapeutics;2023-11-02

5. Efficacy and safety of drug therapy for the prevention and treatment of chemotherapy-induced peripheral neuropathy: a protocol for a systematic review and network meta-analysis;BMJ Open;2023-09