Deregulated coenzyme A, loss of metabolic flexibility and diabetes-Reference-Cited by-同舟云学术

Deregulated coenzyme A, loss of metabolic flexibility and diabetes

Published:2014-08-01 Issue:4 Volume:42 Page:1118-1122
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Jackowski Suzanne¹,Leonardi Roberta²

Affiliation:

1. Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, U.S.A.

2. Department of Biochemistry, School of Medicine, West Virginia University, One Medical Center Drive, Morgantown, WV 26506, U.S.A.

Abstract

CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability of this cofactor to control the output of key metabolic pathways. CoA regulation is important for the maintenance of metabolic flexibility and glucose homoeostasis.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/42/4/1118/434517/bst0421118.pdf

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