LncRNA LOXL1-AS is up-regulated in thoracic aortic aneurysm and regulated proliferation and apoptosis of aortic smooth muscle cells-Reference-Cited by-同舟云学术

LncRNA LOXL1-AS is up-regulated in thoracic aortic aneurysm and regulated proliferation and apoptosis of aortic smooth muscle cells

Published:2019-09 Issue:9 Volume:39 Page:
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Huang Ben¹,Lu Shuyang¹,Lai Hao¹,Li Jun¹,Sun Yongxin¹^ORCID,Wang Chunsheng¹

Affiliation:

1. Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Xietu Road No. 1609, Shanghai City 200032, P.R. China

Abstract

Abstract Long non-coding RNA LOXL1-AS is up-regulated in several types of cancers. The present study was carried out to explore the potential interactions between LOXL1-AS and lncRNA Giver in thoracic aortic aneurysm (TAA). We found that LOXL1-AS was up-regulated in TAA patients than in healthy controls in aortic media specimens. Altered expression levels of LOXL1-AS distinguished TAA patients from healthy controls. LncRNA Giver was also up-regulated in TAA patients than in healthy controls in aortic media specimens, and was positively correlated with LOXL1-AS. LOXL1-AS overexpression mediated the up-regulation of Giver in human aortic smooth muscle cells, while Giver overexpression failed to significantly affect LOXL1-AS. LOXL1-AS and Giver overexpression resulted in promoted proliferation and inhibited apoptosis of HAOSMC. Giver silencing played an opposite role and attenuated the effect of LOXL1-AS overexpression. Therefore, LOXL1-AS was up-regulated in TAA and regulated proliferation and apoptosis of LOXL1-AS by up-regulating Giver.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20191649/854828/bsr-2019-1649.pdf

Reference17 articles.

1. Ten years experience of thoracic and thoracoabdominal aortic aneurysm surgical repair: lessons learned;Chiesa;Ann. Vasc. Surg.,2004

2. Heterozygous TGFBR2 mutations in Marfan syndrome;Mizuguchi;Nat. Genet.,2004

3. Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV;Schwarze;Am. J. Hum. Genet.,2001

4. A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection;Chen;J. Thorac. Cardiovasc. Surg.,2006

5. Complications of major aortic and lower extremity vascular surgery;Ghansah;Semin. Cardiothorac. Vasc. Anesth.,2004

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pathogenetic significance of long non-coding RNAs in the development of thoracic and abdominal aortic aneurysms;Биохимия;2024-07-31

2. The Role of Long Non-Coding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms;Journal of Cardiovascular Pharmacology;2024-04-09

3. Resveratrol improves meat quality traits by activating the lncRNAs-KEAP1-NRF2 axis in pigs;Meat Science;2024-03

4. Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms;Biochemistry (Moscow);2024-01

5. Multi-omics in thoracic aortic aneurysm: the complex road to the simplification;Cell & Bioscience;2023-07-20