Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes-Reference-Cited by-同舟云学术

Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes

Published:1991-11-15 Issue:1 Volume:280 Page:273-276
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Sanchez-Bueno A¹,Sancho M J²,Cobbold P H¹

Affiliation:

1. Department of Human Anatomy and Cell Biology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.

2. Department of Biochemistry, Faculty of Sciences, University of The Basque Country, 48080 Bilbao, Spain

Abstract

Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/280/1/273/605105/bj2800273.pdf

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