The life and death of translation elongation factor 2-Reference-Cited by-同舟云学术

The life and death of translation elongation factor 2

Published:2006-01-20 Issue:1 Volume:34 Page:1-6
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Jørgensen R.¹,Merrill A.R.¹,Andersen G.R.²

Affiliation:

1. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1

2. Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000, Denmark

Abstract

eEF2 (eukaryotic elongation factor 2) occupies an essential role in protein synthesis where it catalyses the translocation of the two tRNAs and the mRNA after peptidyl transfer on the 80 S ribosome. Recent crystal structures of eEF2 and the cryo-electron microscopy reconstruction of its 80 S complex now provide a substantial structural framework for dissecting the functional properties of this factor. The factor can be modified by either phosphorylation or ADP-ribosylation, which results in cessation of translation. We review the structural and functional properties of eEF2 with particular emphasis on the unique diphthamide residue, which is ADP-ribosylated by diphtheria toxin from Corynebacterium diphtheriae and exotoxin A from Pseudomonas aeruginosa.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/34/1/1/541359/bst0340001.pdf

Reference52 articles.

1. Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

2. Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site 1 1Edited by I. A. Wilson

3. Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

4. Conformationally Restricted Elongation Factor G Retains GTPase Activity but Is Inactive in Translocation on the Ribosome

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