13C- and 1H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived chloromethane and glyoxal inhibitors
Author:
Affiliation:
1. UCD School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Dublin 4, Ireland
Abstract
Publisher
Portland Press Ltd.
Subject
Biochemistry
Link
https://portlandpress.com/biochemsoctrans/article-pdf/35/3/566/541663/bst0350566.pdf
Reference48 articles.
1. Serine Protease Mechanism and Specificity
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3. 13C NMR of enzymes
4. Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor
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3. Importance of Tetrahedral Intermediate Formation in the Catalytic Mechanism of the Serine Proteases Chymotrypsin and Subtilisin;Biochemistry;2012-07-25
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