Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine-Reference-Cited by-同舟云学术

Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine

Published:2008-06-02 Issue:1 Volume:115 Page:13-23
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Sommer Grit¹,Garten Antje²,Petzold Stefanie²,Beck-Sickinger Annette G.³,Blüher Matthias¹,Stumvoll Michael¹,Fasshauer Mathias¹⁴

Affiliation:

1. Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany

2. Hospital for Children and Adolescents, University of Leipzig, 04317 Leipzig, Germany

3. Institute of Biochemistry, University of Leipzig, 04103 Leipzig, Germany

4. Interdisciplinary Centre for Clinical Research (IZKF), 04103 Leipzig, Germany

Abstract

Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/115/1/13/438813/cs1150013.pdf

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4. Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866;Kim;J. Mol. Biol.,2006

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