THE CONTRIBUTION OF CURRENT LABORATORY METHODS IN CONDUCTING BIOLOGICAL MONITORING OF LEAD EXPOSURE TO THE WORKERS OF A LEAD RECYCLING PLANT

Author:

Kuzmina L.P.,Khotuleva A.G.,Bezrukavnikova L.M.,Sorkina N.S.,Tsidilkovskaya E.S.

Abstract

To assess the informative value of the expansion of the laboratory tests complex in conducting biological monitoring of lead exposure to the organism, in workers of a lead recycling plant there were determined iron and ferritin levels for the analysis of the association of iron metabolism disorders with chronic exposure to lead, polymorphisms of the hemochromatosis gene as a risk factor for increased lead absorption, erythrocytes and reticulocytes parameters for the detection of early signs of toxic effects of lead on erythropoiesis. There was determined an importance of an estimation of an iron metabolism in workers exposed to lead for detecting risk groups of conditions connected with an iron overload. To assess the early signs of the toxic effect of lead on erythropoiesis, it is informative not only to determine the amount of reticulocytes, but also to estimate the ratio of reticulocyte fractions. The determination of the polymorphism of the hemochromatosis gene can be used to assess the individual risk of developing lead poisoning.

Publisher

Federal Center for Hygiene and Epidemiology

Reference13 articles.

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