Efficacy of Midazolam Vs Diazepam in The Treatment of Status Epilepticus

Abstract

Managing status epilepticus remains a formidable task in contemporary epilepsy care. This persistent and self-perpetuating epileptic activity presents with various manifestations with generalized convulsions being the prevailing form. Objective: To compare the efficacy of intravenous Midazolam with intravenous Diazepam in the treatment of status epilepticus. Methods: It was a Randomized controlled trial conducted at Pediatric Department, Lady Reading Hospital Peshawar. All new cases of SE were enrolled in study in OPD. Patients in group A were subjected to intravenous midazolam (0.2 mg/kg body weight infused in normal saline over 10 mins) and patients in group B were subjected to DZP (0.15mg/kg body weight infused in normal saline over 10 mins). All children were carefully monitored for the cessation of SE. Results: Out of the 120 cases included in the study, 72 (60.0%) were male patients, and 48 (40.0%) were female patients. The average age of the study participants was 3.67 ± 1.81 years. Among these 120 cases, 77 (64.2%) resided in rural areas, while 43 (35.8%) lived in urban areas. Efficacy was noted in 97 (80.8%) of our study cases, efficacy in group A was noted to be in 56 (93.3%) while in group B efficacy was noted to be in 41 (68.3%) (p = 0.001). Conclusions: Our study results support the use of Midazolam as it was found to be safe, effective and reliable as compared with Diazepam, as efficacy was significantly more common in Midazolam group.