EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION-Reference-Cited by-同舟云学术

EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION

Published:2018-07-19 Issue:6 Volume:96 Page:45-50
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Tikhonova L. Yu.,Sokolova V. V.,Tarasyuk I. A.,Ekimenko A. M.,Cherenkova M. A.,Kudlay D. A.

Abstract

The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.

Publisher

New Terra

Subject

General Medicine

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