Author:
Cao Ke-Sheng,Xue Ling-Wei,Liu Qiao-Ru
Abstract
A mononuclear copper(II) complex [CuLa] (1), and three mononuclear nickel(II) complexes [NiLa] (2), [NiLa]·CH3OH (2·CH3OH) and [NiLb] (3), where La and Lb are the dianionic form of N,N’-bis(4-bromosalicylidene)-1,2-cyclohexanediamine (H2La) and N,N’-bis(4-fluorosalicylidene)-1,2-cyclohexanediamine (H2Lb), respectively, were prepared and structurally characterized by spectroscopy method and elemental analyses. The detailed structures were determined by X-ray single crystal diffraction. All the copper and nickel complexes are mononuclear compounds. The metal ions in the complexes are in square planar coordination, with the two phenolate oxygens and two imine nitrogens of the Schiff base ligands. The biological effect of the four complexes were assayed on the bacteria strains Staphylococcus aureus, Escherichia coli and Candida albicans, which show that the substituent groups of the ligands and the metal ions can influence the antimicrobial activities. Complexes 1 and 3 have strong activity against Staphylococcus aureus and Escherichia coli, which are comparable to the reference drug tetracycline.
Publisher
Slovenian Chemical Society
Cited by
1 articles.
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