Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis
Author:
Affiliation:
1. Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha
Publisher
American Medical Association (AMA)
Subject
General Medicine
Link
https://jamanetwork.com/journals/jama/articlepdf/2759413/jama_kalil_2020_ed_190130.pdf
Reference19 articles.
1. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study.;Marik;Chest,2017
2. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial [published online January 17, 2020].;Fujii;JAMA
3. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock.;Woolum;Crit Care Med,2018
4. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study.;Donnino;Crit Care Med,2016
5. The effects of intravenous antioxidants in patients with septic shock.;Galley;Free Radic Biol Med,1997
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