Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

Author:

Holcomb John B.1,Tilley Barbara C.2,Baraniuk Sarah2,Fox Erin E.1,Wade Charles E.1,Podbielski Jeanette M.1,del Junco Deborah J.1,Brasel Karen J.3,Bulger Eileen M.4,Callcut Rachael A.5,Cohen Mitchell Jay5,Cotton Bryan A.1,Fabian Timothy C.6,Inaba Kenji7,Kerby Jeffrey D.8,Muskat Peter9,O’Keeffe Terence10,Rizoli Sandro11,Robinson Bryce R. H.12,Scalea Thomas M.13,Schreiber Martin A.14,Stein Deborah M.13,Weinberg Jordan A.6,Callum Jeannie L.15,Hess John R.16,Matijevic Nena1,Miller Christopher N.17,Pittet Jean-Francois18,Hoyt David B.19,Pearson Gail D.20,Leroux Brian21,van Belle Gerald22

Affiliation:

1. Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center, Houston

2. Division of Biostatistics, School of Public Health, University of Texas Health Science Center, Houston

3. Division of Trauma and Critical Care, Department of Surgery, Medical College of Wisconsin, Milwaukee22Dr Brasel is now with the Division of Trauma, Critical Care and Acute Care Surgery, School of Medicine, Oregon Health & Science University, Portland

4. Division of Trauma and Critical Care, Department of Surgery, School of Medicine, University of Washington, Seattle

5. Division of General Surgery, Department of Surgery, School of Medicine, University of California, San Francisco

6. Division of Trauma and Surgical Critical Care, Department of Surgery, College of Medicine, University of Tennessee Health Science Center, Memphis

7. Division of Trauma and Critical Care, University of Southern California, Los Angeles

8. Division of Trauma, Burns and Surgical Critical Care, Department of Surgery, School of Medicine, University of Alabama, Birmingham

9. Division of Trauma/Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio23Dr Muskat is now with the Division of General Surgery, Department of Surgery, School of Medicine, University of California, San Franc

10. Division of Trauma, Critical Care and Emergency Surgery, Department of Surgery, University of Arizona, Tucson

11. Trauma and Acute Care Surgery, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

12. Division of Trauma/Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio

13. R. Adams Cowley Shock Trauma Center, Program in Trauma, University of Maryland School of Medicine, Baltimore

14. Division of Trauma, Critical Care and Acute Care Surgery, School of Medicine, Oregon Health & Science University, Portland

15. Sunnybrook Research Institute, Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

16. Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle

17. Department of Emergency Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio

18. Division of Critical Care and Perioperative Medicine, Department of Anesthesiology, School of Medicine, University of Alabama, Birmingham

19. American College of Surgeons, Chicago, Illinois

20. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

21. Department of Biostatistics, School of Public Health, University of Washington, Seattle

22. Department of Biostatistics, School of Public Health, University of Washington, Seattle21Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle

Publisher

American Medical Association (AMA)

Subject

General Medicine

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