Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021-Reference-Cited by-同舟云学术

Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021

Published:2022-10-25 Issue:16 Volume:328 Page:1604
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

,Wulf Hanson Sarah¹,Abbafati Cristiana²,Aerts Joachim G.³,Al-Aly Ziyad⁴⁵,Ashbaugh Charlie¹,Ballouz Tala⁶,Blyuss Oleg⁷⁸,Bobkova Polina⁹,Bonsel Gouke¹⁰,Borzakova Svetlana¹¹¹²,Buonsenso Danilo¹³¹⁴,Butnaru Denis¹⁵,Carter Austin¹,Chu Helen¹⁶,De Rose Cristina¹³,Diab Mohamed Mustafa¹⁷¹⁸,Ekbom Emil¹⁹,El Tantawi Maha²⁰,Fomin Victor²¹,Frithiof Robert²²,Gamirova Aysylu²³,Glybochko Petr V.²⁴,Haagsma Juanita A.²⁵,Haghjooy Javanmard Shaghayegh²⁶,Hamilton Erin B.¹,Harris Gabrielle²⁷,Heijenbrok-Kal Majanka H.²⁸²⁹,Helbok Raimund³⁰,Hellemons Merel E.³,Hillus David³¹,Huijts Susanne M.³²,Hultström Michael²²³³,Jassat Waasila³⁴,Kurth Florian³⁵³⁶,Larsson Ing-Marie²²,Lipcsey Miklós²²,Liu Chelsea³⁷,Loflin Callan D.²⁷,Malinovschi Andrei³⁸,Mao Wenhui¹⁷³⁹,Mazankova Lyudmila⁴⁰,McCulloch Denise¹⁶,Menges Dominik⁶,Mohammadifard Noushin⁴¹,Munblit Daniel⁸⁴²,Nekliudov Nikita A.²³,Ogbuoji Osondu³⁹,Osmanov Ismail M.¹¹⁴³,Peñalvo José L.⁴⁴⁴⁵,Petersen Maria Skaalum⁴⁶⁴⁷,Puhan Milo A.⁶⁴⁸,Rahman Mujibur⁴⁹,Rass Verena³⁰,Reinig Nickolas¹,Ribbers Gerard M.²⁸,Ricchiuto Antonia⁵⁰,Rubertsson Sten²²⁵¹,Samitova Elmira⁴⁰⁴³,Sarrafzadegan Nizal⁴¹⁵²,Shikhaleva Anastasia⁹,Simpson Kyle E.¹,Sinatti Dario¹³,Soriano Joan B.⁵³⁵⁴,Spiridonova Ekaterina²³,Steinbeis Fridolin³¹,Svistunov Andrey A.²⁴,Valentini Piero¹³,van de Water Brittney J.⁵⁵⁵⁶,van den Berg-Emons Rita²⁸,Wallin Ewa²²,Witzenrath Martin³⁵⁵⁷,Wu Yifan¹,Xu Hanzhang⁵⁸,Zoller Thomas³¹,Adolph Christopher⁵⁹⁶⁰,Albright James¹,Amlag Joanne O.¹,Aravkin Aleksandr Y.¹⁶¹⁶²,Bang-Jensen Bree L.¹,Bisignano Catherine¹,Castellano Rachel¹,Castro Emma¹,Chakrabarti Suman¹⁶³,Collins James K.¹,Dai Xiaochen¹⁶²,Daoud Farah¹,Dapper Carolyn¹,Deen Amanda¹,Duncan Bruce B.⁶⁴,Erickson Megan¹,Ewald Samuel B.¹,Ferrari Alize J.¹⁶⁵,Flaxman Abraham D.¹⁶²,Fullman Nancy¹,Gamkrelidze Amiran⁶⁶,Giles John R.¹,Guo Gaorui¹,Hay Simon I.¹⁶²,He Jiawei¹,Helak Monika¹,Hulland Erin N.¹⁶³,Kereselidze Maia⁶⁶,Krohn Kris J.¹,Lazzar-Atwood Alice¹,Lindstrom Akiaja⁶⁵⁶⁷,Lozano Rafael¹⁶²,Malta Deborah Carvalho⁶⁸,Månsson Johan¹,Mantilla Herrera Ana M.⁶⁵⁶⁹,Mokdad Ali H.¹⁶²,Monasta Lorenzo⁷⁰,Nomura Shuhei⁷¹⁷²,Pasovic Maja¹,Pigott David M.¹⁶²,Reiner Robert C.¹⁶²,Reinke Grace¹,Ribeiro Antonio Luiz P.⁷³⁷⁴,Santomauro Damian Francesco¹⁶⁵⁷⁵,Sholokhov Aleksei¹,Spurlock Emma Elizabeth¹⁷⁶,Walcott Rebecca⁷⁷,Walker Ally¹,Wiysonge Charles Shey⁷⁸⁷⁹,Zheng Peng¹⁶²,Bettger Janet Prvu⁸⁰,Murray Christopher J. L.¹⁶²,Vos Theo¹⁶²

Affiliation:

1. Institute for Health Metrics and Evaluation, University of Washington, Seattle

2. Department of Juridical and Economic Studies, La Sapienza University, Rome, Italy

3. Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

4. John T. Milliken Department of Internal Medicine, Washington University in St Louis, St Louis, Missouri

5. Clinical Epidemiology Center, US Department of Veterans Affairs, St Louis, Missouri

6. Epidemiology, Biostatistics, and Prevention Institute, University of Zürich, Zurich, Switzerland

7. Wolfson Institute of Population Health, Queen Mary University of London, London, England

8. Department of Pediatrics and Pediatric Infectious Diseases, I. M. Sechenov First Moscow State Medical University, Moscow, Russia

9. Clinical Medicine (Pediatric Profile), I. M. Sechenov First Moscow State Medical University, Moscow, Russia

10. EuroQol Research Foundation, Rotterdam, the Netherlands

11. Pirogov Russian National Research Medical University, Moscow

12. Research Institute for Healthcare Organization and Medical Management, Moscow Healthcare Department, Moscow, Russia

13. Department of Woman and Child Health and Public Health, Agostino Gemelli University Polyclinic IRCCS, Rome, Italy

14. Global Health Research Institute, Catholic University of Sacred Heart, Rome, Italy

15. I. M. Sechenov First Moscow State Medical University, Moscow, Russia

16. Department of Medicine, University of Washington, Seattle

17. Center for Policy Impact in Global Health, Duke University, Durham, North Carolina

18. Department of Surgery, Duke University, Durham, North Carolina

19. Uppsala University Hospital, Uppsala, Sweden

20. Pediatric Dentistry and Dental Public Health Department, Alexandria University, Alexandria, Egypt

21. Rector’s Office, I. M. Sechenov First Moscow State Medical University, Moscow, Russia

22. Department of Surgical Sciences, Anesthesiology, and Intensive Care Medicine, Uppsala University, Uppsala, Sweden

23. Clinical Medicine (General Medicine Profile), I. M. Sechenov First Moscow State Medical University, Moscow, Russia

24. Administration Department, I. M. Sechenov First Moscow State Medical University, Moscow, Russia

25. Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands

26. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

27. School of Nursing, Duke University, Durham, North Carolina

28. Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

29. Neurorehabilitation, Rijndam Rehabilitation, Rotterdam, the Netherlands

30. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

31. Department of Infectious Diseases and Respiratory Medicine, Charité Medical University Berlin, Berlin, Germany

32. Department of Respiratory Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

33. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

34. Department of Public Health Surveillance and Response, National Institute for Communicable Diseases, Johannesburg, South Africa

35. Department of Infectious Diseases and Respiratory Medicine, Charité University Medical Center Berlin, Berlin, Germany

36. Department of Clinical Research and Tropical Medicine, Bernhard-Nocht Institute of Tropical Medicine, Hamburg, Germany

37. Department of Epidemiology, Harvard University, Boston, Massachusetts

38. Department of Medical Sciences, Uppsala University, Uppsala, Sweden

39. Duke Global Health Institute, Duke University, Durham, North Carolina

40. Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare of the Russian Federation, Moscow

41. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

42. National Heart and Lung Institute, Imperial College London, London, England

43. ZA Bashlyaeva Children’s Municipal Clinical Hospital, Moscow, Russia

44. Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium

45. Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts

46. Department of Occupational Medicine and Public Health, Faroese Hospital System, Torshavn, Faroe Islands

47. Centre of Health Science, University of Faroe Islands, Torshavn

48. Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland

49. Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

50. Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

51. Department of Surgical Sciences, Hedenstierna Laboratory, Uppsala University, Uppsala, Sweden

52. School of Population and Public Health, University of British Columbia, Vancouver, Canada

53. Hospital Universitario de La Princesa, Madrid, Spain

54. Centro de Investigación Biomédica en Red Enfermedades Respiratorias (Center for Biomedical Research in Respiratory Diseases Network), Madrid, Spain

55. Department of Global Health and Social Medicine, Harvard University, Boston, Massachusetts

56. Nursing and Midwifery Department, Seed Global Health, Boston, Massachusetts

57. German Center for Lung Research, Berlin

58. Department of Family Medicine and Community Health, Duke University, Durham, North Carolina

59. Department of Political Science, University of Washington, Seattle

60. Center for Statistics and the Social Sciences, University of Washington, Seattle

61. Department of Applied Mathematics, University of Washington, Seattle

62. Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle

63. Department of Global Health, University of Washington, Seattle

64. Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

65. School of Public Health, University of Queensland, Brisbane, Australia

66. National Center for Disease Control and Public Health, Tbilisi, Georgia

67. School of Public Health, Queensland Centre for Mental Health Research, Wacol, Australia

68. Department of Maternal and Child Nursing and Public Health, Federal University of Minas Gerais, Belo Horizonte, Brazil

69. West Moreton Hospital Health Services, Queensland Centre for Mental Health Research, Wacol, Australia

70. Clinical Epidemiology and Public Health Research Unit, Burlo Garofolo Institute for Maternal and Child Health, Trieste, Italy

71. Department of Health Policy and Management, Keio University, Tokyo, Japan

72. Department of Global Health Policy, University of Tokyo, Tokyo, Japan

73. Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil

74. Centre of Telehealth, Federal University of Minas Gerais, Belo Horizonte, Brazil

75. Policy and Epidemiology Group, Queensland Centre for Mental Health Research, Wacol, Australia

76. Department of Social and Behavioral Sciences, School of Public Health, Yale University, New Haven, Connecticut

77. Evans School of Public Policy and Governance, University of Washington, Seattle

78. Cochrane South Africa, South African Medical Research Council, Cape Town

79. HIV and Other Infectious Diseases Research Unit, South African Medical Research Council, Durban

80. Department of Orthopedic Surgery, Duke University, Durham, North Carolina

Abstract

ImportanceSome individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).ObjectiveTo estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.Design, Setting, and ParticipantsBayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022.ExposuresSymptomatic SARS-CoV-2 infection.Main Outcomes and MeasuresProportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age.ResultsA total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ongoing respiratory problems, and 2.2% (95% UI, 0.3%-7.6%) for cognitive problems after adjusting for health status before COVID-19, comprising an estimated 51.0% (95% UI, 16.9%-92.4%), 60.4% (95% UI, 18.9%-89.1%), and 35.4% (95% UI, 9.4%-75.1%), respectively, of Long COVID cases. The Long COVID symptom clusters were more common in women aged 20 years or older (10.6% [95% UI, 4.3%-22.2%]) 3 months after symptomatic SARS-CoV-2 infection than in men aged 20 years or older (5.4% [95% UI, 2.2%-11.7%]). Both sexes younger than 20 years of age were estimated to be affected in 2.8% (95% UI, 0.9%-7.0%) of symptomatic SARS-CoV-2 infections. The estimated mean Long COVID symptom cluster duration was 9.0 months (95% UI, 7.0-12.0 months) among hospitalized individuals and 4.0 months (95% UI, 3.6-4.6 months) among nonhospitalized individuals. Among individuals with Long COVID symptoms 3 months after symptomatic SARS-CoV-2 infection, an estimated 15.1% (95% UI, 10.3%-21.1%) continued to experience symptoms at 12 months.Conclusions and RelevanceThis study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2797443/jama_wulf_hanson_2022_oi_220113_1666033246.84384.pdf

Reference88 articles.

1. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome: a case-controlled study.;Moldofsky;BMC Neurol,2011

2. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study.;Hickie;BMJ,2006

3. Long covid—mechanisms, risk factors, and management.;Crook;BMJ,2021

4. NICE guideline on Long COVID.;Venkatesan;Lancet Respir Med,2021

5. Post–COVID-19 Syndrome (Long Haul Syndrome): description of a multidisciplinary clinic at Mayo Clinic and characteristics of the initial patient cohort.;Vanichkachorn;Mayo Clin Proc,2021

Cited by 310 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Factores genéticos asociados a long COVID;Medicina de Familia. SEMERGEN;2024-03

2. Post-viral symptoms and conditions are more frequent in COVID-19 than influenza, but not more persistent;2024-02-06

3. Patient Experiences Navigating Care Coordination For Long COVID: A Qualitative Study;Journal of General Internal Medicine;2024-02-02

4. Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative data;The Lancet Regional Health - Americas;2024-02

5. Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis;Journal of Infection;2024-02