Futility in Clinical Trials-Reference-Cited by-同舟云学术

Futility in Clinical Trials

Published:2023-08-22 Issue:8 Volume:330 Page:764
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Wendelberger Barbara¹,Lewis Roger J.¹²³

Affiliation:

1. Berry Consultants LLC, Austin, Texas

2. Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California

3. Statistical Editor, JAMA

Abstract

This JAMA Guide to Statistics and Methods discusses the early stopping of clinical trials for futility due to lack of evidence supporting the desired benefit, evidence of harm, or practical issues that make successful completion unlikely.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2808097/jama_wendelberger_2023_gm_230001_1692287140.73253.pdf

Reference10 articles.

1. Early termination of clinical trials for futility—considerations for a data and safety monitoring board.;Ellenberg;NEJM Evidence,2022

2. Effect of direct transportation to thrombectomy-capable center vs local stroke center on neurological outcomes in patients with suspected large-vessel occlusion stroke in nonurban areas: the RACECAT randomized clinical trial.;Pérez de la Ossa;JAMA,2022

3. Group sequential clinical trials with triangular continuation regions.;Whitehead;Biometrics,1983

4. Conditional power: how likely is trial success?;Saville;JAMA,2023

5. Pro/con clinical debate: it is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility.;Schoenfeld;Crit Care,2005

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