Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

Author:

Rubenstein Richard1,Chang Binggong1,Yue John K.2,Chiu Allen1,Winkler Ethan A.3,Puccio Ava M.4,Diaz-Arrastia Ramon5,Yuh Esther L.6,Mukherjee Pratik6,Valadka Alex B.7,Gordon Wayne A.8,Okonkwo David O.4,Davies Peter9,Agarwal Sanjeev10,Lin Fan11,Sarkis George12,Yadikar Hamad13,Yang Zhihui11,Manley Geoffrey T.3,Wang Kevin K. W.11,Cooper Shelly R.14,Dams-O’Connor Kristen8,Borrasso Allison J.4,Inoue Tomoo3,Maas Andrew I. R.15,Menon David K.16,Schnyer David M.17,Vassar Mary J.3,

Affiliation:

1. Laboratory of Neurodegenerative Diseases and CNS Biomarker Discovery, Departments of Neurology and Physiology/Pharmacology, State University of New York Downstate Medical Center, Brooklyn

2. Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, California

3. Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, California3Department of Neurological Surgery, University of California, San Francisco

4. Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

5. University of Pennsylvania Perelman School of Medicine, Philadelphia

6. Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, California6Department of Radiology, University of California, San Francisco

7. Department of Neurosurgery, Virginia Commonwealth University, Richmond

8. Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York

9. Litwin-Zucker Center for Research in Alzheimer’s Disease, Feinstein Institute for Medical Research, Manhasset, New York

10. Department of Orthopedic Surgery and Rehabilitation Medicine, State University of New York Downstate Medical Center, Brooklyn

11. Program for Neurotrauma, Neuroproteomics, and Biomarker Research, Department of Emergency Medicine, Psychiatry and Chemistry, University of Florida, Gainesville

12. Program for Neurotrauma, Neuroproteomics, and Biomarker Research, Department of Emergency Medicine, Psychiatry and Chemistry, University of Florida, Gainesville12Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria, Egypt

13. Program for Neurotrauma, Neuroproteomics, and Biomarker Research, Department of Emergency Medicine, Psychiatry and Chemistry, University of Florida, Gainesville13Department of Biochemistry, Kuwait University, Khadiya, Kuwait

14. Department of Psychology, Washington University, St Louis, Missouri

15. Department of Neurosurgery, Antwerp University Hospital, Edegem, Belgium

16. Departments of Anesthesia and Neurocritical Care, University of Cambridge, Cambridge, England

17. Department of Psychology, University of Texas, Austin

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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