A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

Author:

,Beal M. Flint1,Oakes David2,Shoulson Ira3,Henchcliffe Claire1,Galpern Wendy R.4,Haas Richard5,Juncos Jorge L.6,Nutt John G.7,Voss Tiffini Smith8,Ravina Bernard9,Shults Clifford M.10,Helles Karen2,Snively Victoria2,Lew Mark F.11,Griebner Brian2,Watts Arthur12,Gao Shan2,Pourcher Emmanuelle13,Bond Louisette13,Kompoliti Katie14,Agarwal Pinky15,Sia Cherissa15,Jog Mandar16,Cole Linda16,Sultana Munira16,Kurlan Roger17,Richard Irene18,Deeley Cheryl18,Waters Cheryl H.19,Figueroa Angel19,Arkun Ani1,Brodsky Matthew7,Ondo William G.20,Hunter Christine B.21,Jimenez-Shahed Joohi21,Palao Alicia21,Miyasaki Janis M.22,So Julie22,Tetrud James23,Reys Liza23,Smith Katharine23,Singer Carlos24,Blenke Anita24,Russell David S.25,Cotto Candace25,Friedman Joseph H.26,Lannon Margaret27,Zhang Lin28,Drasby Edward29,Kumar Rajeev30,Subramanian Thyagarajan31,Ford Donna Stuppy31,Grimes David A.32,Cote Diane32,Conway Jennifer32,Siderowf Andrew D.33,Evatt Marian Leslie34,Sommerfeld Barbara6,Lieberman Abraham N.35,Okun Michael S.36,Rodriguez Ramon L.36,Merritt Stacy36,Swartz Camille Louise36,Martin W. R. Wayne37,King Pamela37,Stover Natividad38,Guthrie Stephanie38,Watts Ray L.38,Ahmed Anwar39,Fernandez Hubert H.39,Winters Adrienna39,Mari Zoltan40,Dawson Ted M.40,Dunlop Becky40,Feigin Andrew S.41,Shannon Barbara41,Nirenberg Melissa Jill42,Ogg Mattson1,Ellias Samuel A.43,Thomas Cathi-Ann43,Frei Karen44,Bodis-Wollner Ivan45,Glazman Sofya45,Mayer Thomas45,Hauser Robert A.46,Pahwa Rajesh47,Langhammer April47,Ranawaya Ranjit48,Derwent Lorelei48,Sethi Kapil D.49,Farrow Buff49,Prakash Rajan49,Litvan Irene5,Robinson Annette50,Sahay Alok51,Gartner Maureen51,Hinson Vanessa K.52,Markind Samuel53,Pelikan Melisa53,Perlmutter Joel S.54,Hartlein Johanna54,Molho Eric55,Evans Sharon55,Adler Charles H.56,Duffy Amy56,Lind Marlene56,Elmer Lawrence57,Davis Kathy58,Spears Julia58,Wilson Stephanie58,Leehey Maureen A.59,Hermanowicz Neal60,Niswonger Shari60,Shill Holly A.61,Obradov Sanja61,Rajput Alex62,Cowper Marilyn62,Lessig Stephanie63,Song David63,Fontaine Deborah63,Zadikoff Cindy64,Williams Karen64,Blindauer Karen A.65,Bergholte Jo65,Propsom Clara Schindler65,Stacy Mark A.66,Field Joanne66,Mihaila Dragos67,Chilton Mark67,Uc Ergun Y.68,Sieren Jeri68,Simon David K.69,Kraics Lauren69,Silver Althea69,Boyd James T.70,Hamill Robert W.70,Ingvoldstad Christopher70,Young Jennifer70,Thomas Karen71,Kostyk Sandra K.71,Wojcieszek Joanne72,Pfeiffer Ronald F.73,Panisset Michel74,Beland Monica74,Reich Stephen G.75,Cines Michelle75,Zappala Nancy75,Rivest Jean76,Zweig Richard77,Lumina L. Pepper77,Hilliard Colette Lynn78,Grill Stephen40,Kellermann Marye79,Tuite Paul80,Rolandelli Susan80,Kang Un Jung81,Young Joan81,Rao Jayaraman82,Cook Maureen M.82,Severt Lawrence83,Boyar Karyn83

Affiliation:

1. Department of Neurology, Weill Cornell Medical College, New York Hospital, New York

2. Department of Biostatistics, University of Rochester Medical Center, Rochester, New York

3. Department of Neurology, Georgetown University, Washington, DC

4. National Institutes of Health, Bethesda, Maryland

5. Department of Neurosciences, University of California, San Diego, La Jolla

6. Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia

7. Department of Neurology, Oregon Health and Science University, Portland

8. Merck, New Jersey

9. Biogen Idec, Cambridge, Massachusetts

10. Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California

11. Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles

12. Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York

13. Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada

14. Rush University Medical Center, Chicago, Illinois

15. Booth Gardner Parkinson’s Care Center, EvergreenHealth, Kirkland, Washington

16. London Health Sciences Centre, London, Ontario, Canada

17. Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey

18. Department of Neurology, University of Rochester, Rochester, New York

19. Columbia University Medical Center, Neurological Institute, New York, New York

20. Department of Neurology, University of Texas Health Science Center at Houston

21. Department of Neurology, Baylor College of Medicine, Houston, Texas

22. Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

23. The Parkinson's Institute and Clinical Center, Sunnyvale, California

24. Department of Neurology, University of Miami School of Medicine, Miami, Florida

25. Institute for Neurodegenerative Disorders, New Haven, Connecticut

26. Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island

27. Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine

28. Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento

29. Port City Neurology, Inc, Scarborough, Maine

30. Colorado Neurological Institute, Englewood

31. Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey

32. Ottawa Hospital Civic Site, Ottawa, Ontario, Canada

33. Avid Radiopharmaceuticals, Philadelphia, Pennsylvania

34. Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia

35. Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph’s Hospital and Medical Center, Phoenix, Arizona

36. Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville

37. Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada

38. Department of Neurology, University of Alabama at Birmingham

39. Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio

40. Department of Neurology, Johns Hopkins University, Baltimore, Maryland

41. Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York

42. Department of Neurology, New York University Langone Medical Center, New York

43. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts

44. The Parkinson’s and Movement Disorder Institute, Fountain Valley, California

45. State University of New York, Downstate Medical Center, Brooklyn, New York

46. Department of Neurology, University of South Florida, Tampa

47. Department of Neurology, University of Kansas Medical Center, Kansas City

48. Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

49. Department of Neurology, Georgia Health Science University, Augusta

50. Department of Neurology, University of Louisville, Kentucky

51. University of Cincinnati College of Medicine, Cincinnati, Ohio

52. Department of Neurology, Medical University of South Carolina, Charleston

53. Associated Neurologists, PC, Danbury, Connecticut

54. Department of Neurology, Washington University in St Louis, Missouri

55. Movement Disorders Center, Albany Medical Center, Albany, New York

56. Parkinson’s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona

57. Center for Neurological Health, University of Toledo, Toledo, Ohio

58. Department of Neurology, Medical University of Ohio at Toledo

59. Department of Neurology, University of Colorado Health Science Center, Denver

60. Department of Neurology, University of California, Irvine Medical Center, Irvine

61. Banner Sun Health Research Institute, Sun City, Arizona

62. Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada

63. Department of Neurology, University of California, San Diego, La Jolla

64. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

65. Department of Neurology, Medical College of Wisconsin, Milwaukee

66. Department of Neurology, Duke University, Durham, North Carolina

67. State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse

68. Department of Neurology, University of Iowa, Iowa City

69. Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

70. Department of Neurology, University of Vermont College of Medicine, Burlington

71. Department of Neurology, Ohio State University, Columbus

72. Department of Neurology, Indiana University School of Medicine, Indianapolis

73. Department of Neurology, University of Tennessee Health Science Center, Memphis

74. Department of Neurology, CHUM–Hôpital Notre-Dame, Montréal, Québec, Canada

75. Department of Neurology, University of Maryland School of Science, Baltimore

76. Department of Neurology, University of Sherbrooke, Québec, Canada

77. Department of Neurology, Louisiana State University Health Science Center, Shreveport

78. Lewis Hall Singletary Oncology Center, Thomasville, Georgia

79. Parkinson and Movement Disorders Center of Maryland, Elkridge

80. Department of Neurology, University of Minnesota, Minneapolis

81. Department of Neurology, University of Chicago, Chicago, Illinois

82. Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana

83. Department of Neurology, Beth Israel Medical Center, New York, New York

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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